The 30 years of wars or reformation wars of religion were followed by secularization, a seemingly apparent solution to religious intolerance. However, despite the benefits of secularism, it became another challenge to Christianity and won the struggle but not without leaving its taint on Christianity. it was in this context that the missionaries made so much sacrifice and brought the Christian faith to this part of West Africa called Nigeria. As was the case in Europe, the negative impact of secularism persists in Nigeria to date among Christians thereby putting the integrity of the gospel into question. Using a desktop preview method, this paper analyses the negative dimensions of secular humanism, a side word for secularism. The paper further examines their implications on the success of evangelization otherwise known as Christian religious outreach. The Biblical perspective which is considered the central Christian authority is explored as a guide to true Christian humanism.